Improvement of multiple pathophysiological phenotypes ofklotho (kl/kl) mice by adenovirus-mediated expression of theklotho gene

Abstract

We showed that local expression of the klotho gene retards or partially improves pathological abnormalities in several organs of klotho mice after onset of the phenotypes. Therefore, the recombinant adenovirus vector will provide an important tool for investigating the molecular mechanism of the Klotho protein and give clues to understanding the individual disease mechanisms.