Combined Marginal Folate and Riboflavin Status Affect Homocysteine Methylation in Cultured Immortalized Lymphocytes from Persons Homozygous for the MTHFR C677T Mutation

Relation Between Folate Status, a Common Mutation in Methylenetetrahydrofolate Reductase, and Plasma Homocysteine Concentrations

Paul F. Jacques, Andrew G. Bostom, Roger R. Williams et al. · Circulation · 1996 · 1.4K citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection

Atsushi Araki, Yoshiyasu Sako · Journal of Chromatography B Biomedical Sciences and Applications · 1987 · 1.1K citations

Natural Sciences, Biochemistry, Analytical Chemistry +8

A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status

Simonetta Friso, Sang‐Woon Choi, Domenico Girelli et al. · Proceedings of the National Academy of Sciences · 2002 · 931 citations

Medicine, Genetics, Molecular Genetics +17

Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer.

Jing Ma, Meir J. Stampfer, Edward L. Giovannucci et al. · PubMed · 1997 · 794 citations

Medicine, Genetics, Oncology +16

Intermediate homocysteinemia: a thermolabile variant of methylenetetrahydrofolate reductase.

Seok Seon Kang, Jiemin Zhou, Paul Wong et al. · PubMed · 1988 · 598 citations

Life Sciences, Biochemistry, Genetics +14