Concepedia

The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response

Zhiqiang Zhang, Rosane M. B. Teles, Songying Ouyang, Yan Jiang, Shankar S. Iyer, Shivam A. Zaver, Mirjam Schenk, Wenwan Zhong, Zhi Jie Liu, Robert L. Modlin,

Nature Immunology · 2012 · 402 citations · 23 references

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Concepts

References

23

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

Hiroki Ishikawa, Glen N. Barber · Nature · 2008 · 3.5K citations · Full text

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STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

Hiroki Ishikawa, Zhe Ma, Glen N. Barber · Nature · 2009 · 2.7K citations · Full text

, , +14

IFI16 is an innate immune sensor for intracellular DNA

Leonie Unterholzner, Sinéad E. Keating, Marcin Baran et al. · Nature Immunology · 2010 · 1.6K citations · Full text

, , +14

STING is a direct innate immune sensor of cyclic di-GMP

Dara Burdette, Kathryn M. Monroe, Katia Troha et al. · Nature · 2011 · 1.5K citations

, , +12

The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation

Bo Zhong, Yan Yang, Shu Li et al. · Immunity · 2008 · 1.5K citations · Full text

, , +12