Biodistribution characteristics of all-trans retinoic acid incorporated in liposomes and polymeric micelles following intravenous administration

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

Yasuhiro Matsumura, Hiroshi Maeda · PubMed · 1986 · 6.8K citations

Medicine, Oncology, Pharmacology +12

Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia

Meng‐Er Huang, YC Ye, S R Chen et al. · Blood · 1988 · 2.4K citations · Full text

Medicine, Hematology, Oncology +7

Effect of the cholesterol content of small unilamellar liposomes on their stability <i>in vivo</i> and <i>in vitro</i>

Christopher Kirby, Jacqui Clarke, Gregory Gregoriadis · Biochemical Journal · 1980 · 594 citations · Full text

Life Sciences, Biochemistry, Cell Biology +14

Continuous treatment with all-trans retinoic acid causes a progressive reduction in plasma drug concentrations: implications for relapse and retinoid "resistance" in patients with acute promyelocytic leukemia [published erratum appears in Blood 1992 Aug 1;80(3):855]

Josephia R. Muindi, SR Frankel, WH Jr Miller et al. · Blood · 1992 · 411 citations · Full text

Medicine, Hematology, Pharmacology +10

Characterization and anticancer activity of the micelle-forming polymeric anticancer drug adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer.

M. Yokoyama, Masahiro Miyauchi, Nobuko Yamada et al. · PubMed · 1990 · 399 citations

Pharmacy, Medicinal Chemistry, Pharmaceutics +13