Concepedia

Prediction of the Pharmacokinetics of Atorvastatin, Cerivastatin, and Indomethacin Using Kinetic Models Applied to Isolated Rat Hepatocytes

Stuart W. Paine, Alison J. Parker, Philip Gardiner, Peter J. H. Webborn, Robert J. Riley

Drug Metabolism and Disposition · 2008 · 105 citations · 32 references

DOI

References

32

A physiological approach to hepatic drug clearance

G. Wilkinson, David G. Shand · Clinical Pharmacology & Therapeutics · 1975 · 1.9K citations

The Liver: Biology and Pathobiology.

Annals of Internal Medicine · 1983 · 1.6K citations

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Clearance concepts in pharmacokinetics

Malcolm Rowland, Leslie Z. Benet, Garry G. Graham · Journal of Pharmacokinetics and Biopharmaceutics · 1973 · 761 citations

, , +4

The Influence of Nonspecific Microsomal Binding on Apparent Intrinsic Clearance, and Its Prediction from Physicochemical Properties

Rupert P. Austin, Patrick Barton, Scott L. Cockroft et al. · Drug Metabolism and Disposition · 2002 · 399 citations

A UNIFIED MODEL FOR PREDICTING HUMAN HEPATIC, METABOLIC CLEARANCE FROM IN VITRO INTRINSIC CLEARANCE DATA IN HEPATOCYTES AND MICROSOMES

Robert J. Riley, Dermot F. McGinnity, Rupert P. Austin · Drug Metabolism and Disposition · 2005 · 364 citations