In vitro release of the mTOR inhibitor rapamycin from poly(ethylene glycol)-b-poly(ε-caprolactone) micelles

mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

Pradip K. Majumder, Phillip G. Febbo, Rachel Bikoff et al. · Nature Medicine · 2004 · 956 citations

Medicine, Oncology, Urology +15

Micellar carriers based on block copolymers of poly(ε-caprolactone) and poly(ethylene glycol) for doxorubicin delivery

Xintao Shuai, Hua Ai, Norased Nasongkla et al. · Journal of Controlled Release · 2004 · 699 citations

Pharmacy, Pharmaceutics, Pharmacology +17

Safety and Pharmacokinetics of Escalated Doses of Weekly Intravenous Infusion of CCI-779, a Novel mTOR Inhibitor, in Patients With Cancer

Éric Raymond, Jérôme Alexandre, Sandrine Faivre et al. · Journal of Clinical Oncology · 2004 · 500 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +16

Mechanism for Rapid Self-Assembly of Block Copolymer Nanoparticles

Brian K. Johnson, Robert K. Prud’homme · Physical Review Letters · 2003 · 423 citations

Natural Sciences, Chemistry, Materials Science +17

mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer.

Ker Yu, Lourdes Toral‐Barza, Carolyn Discafani et al. · Endocrine Related Cancer · 2001 · 418 citations · Full text

Medicine, Oncology, Pharmacology +17