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Public HealthBiostatisticsExperimental DesignClinical Trial DesignClinical Trial PhasesClinical TrialsRandomized Controlled TrialsSplit-plot DesignsStudy DesignGraphical ModelsMulti-arm Multi-stage DesignPhase Ii Clinical TrialsSequential Clinical Trial DesignTwo-level Factorial DesignsTwo-stage Clinical Trial DesignTwo-stage Sequential Design
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Optimal two-stage designs for phase II clinical trials
Richard Simon · Controlled Clinical Trials · 1989 · 3.6K citations
Designs for Group Sequential Phase II Clinical Trials
M N Chang, Terry M. Therneau, H. Samuel Wieand · Biometrics · 1987 · 135 citations
Medicine, Biostatistics, Oncology +17
Multiple-Stage Procedures for Drug Screening
John R. Schultz, F. Richard Nichol, Gary Elfring et al. · Biometrics · 1973 · 89 citations
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Y. J. Lee, M. Staquet, Richard Simon et al. · PubMed · 1980 · 48 citations
Medicine, Oncology, Pharmacology +16