Concepedia

Two-stage Sequential Design

Two-Stage Sequential Design is a statistical inference framework in bioequivalence assessment that belongs to the class of adaptive clinical trial designs and is distinguished by its structured, pre-specified two-phase approach wherein the first stage estimates key parameters to inform the sample size and decision rules of a subsequent confirmatory stage, thereby optimizing trial efficiency and regulatory decision-making for Highly Variable Drug Products.

489

Publications

31.8K

Citations

2K

Authors

839

Institutions

Publications per year

2017–2026

101

Parents

Publications

489

Optimal two-stage designs for phase II clinical trials

Richard Simon · Controlled Clinical Trials · 1989 · 3.6K citations

, , +10

Sampling Methods for Random Digit Dialing

Joseph Waksberg · Journal of the American Statistical Association · 1978 · 1.4K citations

, , +15

Reducing and meta-analysing estimates from distributed lag non-linear models

Antonio Gasparrini, Ben Armstrong · BMC Medical Research Methodology · 2013 · 1.1K citations · Full text

, , +11

Group Sequential Methods with Applications to Clinical Trials

KyungMann Kim · Controlled Clinical Trials · 2001 · 713 citations

, , +11

Does Diversity Matter for Health? Experimental Evidence from Oakland

Marcella Alsan, Owen Garrick, Grant Graziani · American Economic Review · 2019 · 675 citations · Full text

, , +17

1–5 of 489

Authors

2K

  1. JW
    John Whitehead

    University of Reading, United Kingdom

    12 publications · 1.6K citations

    12

    h-index

  2. MK
    Meinhard Kieser

    Heidelberg University, Germany

    12 publications · 511 citations

    11

    h-index

  3. GS
    Guogen Shan

    University of Nevada, Las Vegas, United States

    8 publications · 142 citations

    8

    h-index

  4. NS
    Nigel Stallard

    University of Warwick, United Kingdom

    6 publications · 388 citations

    6

    h-index

  5. PB
    Péter Bauer

    Statistics Austria, Austria

    6 publications · 666 citations

    6

    h-index

1–5 of 2K

Institutions

839

  1. Memorial Sloan Kettering Cancer Center

    New York, United States

    13 h-index

    80 publications

    4.9K citations

  2. National Cancer Institute

    Bethesda, United States

    12 h-index

    64 publications

    7.6K citations

  3. Heidelberg University

    Heidelberg, Germany

    11 h-index

    44 publications

    899 citations

  4. Duke University

    Durham, United States

    11 h-index

    13 publications

    836 citations

  5. Harvard University

    Cambridge, United States

    10 h-index

    20 publications

    4.3K citations

  6. University of Wisconsin–Madison

    Madison, United States

    10 h-index

    15 publications

    2.1K citations

  7. University of Reading

    Reading, United Kingdom

    10 h-index

    14 publications

    809 citations

  8. MRC Biostatistics Unit

    Cambridge, United Kingdom

    10 h-index

    14 publications

    381 citations

1–8 of 839

Venues

  1. Statistics in Medicine

    65 publications · 3.4K citations

    29

    h-index

  2. Journal of Clinical Oncology

    30 publications · 2.3K citations

    19

    h-index

  3. Biometrics

    29 publications · 2K citations

    19

    h-index

  4. Biometrical Journal

    16 publications · 471 citations

    14

    h-index

  5. Journal of Biopharmaceutical Statistics

    JBS · 21 publications · 459 citations

    14

    h-index

1–5