Optimal two-stage designs for phase II clinical trials

A Multiple Testing Procedure for Clinical Trials

Peter C. O’Brien, Thomas R. Fleming · Biometrics · 1979 · 3.3K citations

Public Health, Biostatistics, Evidence-based Practice +13

One-Sample Multiple Testing Procedure for Phase II Clinical Trials

Thomas R. Fleming · Biometrics · 1982 · 997 citations

Medicine, Oncology, Clinical Trial Regulation +13

The determination of the number of patients required in a preliminary and a follow-up trial of a new chemotherapeutic agent

Edmund A. Gehan · Journal of Chronic Diseases · 1961 · 670 citations

Medicine, Oncology, Pharmacology +3

Biopharmaceutical Statistics for Drug Development.

Kathleen R. Lamborn, Karl E. Peace · Journal of the American Statistical Association · 1989 · 302 citations

Medicine, Biostatistics, Pharmacology +7

Predictive Probability Early Termination Plans For Phase II Clinical Trials

Jay Herson · Biometrics · 1979 · 142 citations

Public Health, Biostatistics, Epidemiologic Methods +16