Multi-arm Multi-stage Design

Multi-Arm Multi-Stage Design is a sequential experimental design that belongs to the class of clinical trial methodologies, distinguished by its incorporation of multiple treatment arms evaluated across successive stages with interim analyses to selectively continue or drop arms based on accumulating evidence.

Publications

3.6K

Citations

350

Authors

186

Institutions

Publications per year

2017–2026

Variants

Mams Design

Parents

Sequential Experimentation

Publications

Survival with Newly Diagnosed Metastatic Prostate Cancer in the “Docetaxel Era”: Data from 917 Patients in the Control Arm of the STAMPEDE Trial (MRC PR08, CRUK/06/019)

Nicholas D. James, Melissa Spears, Noel W. Clarke et al. · European Urology · 2014 · 436 citations · Full text

Medicine, Biostatistics, Oncology +17

High-dose rifampicin, moxifloxacin, and SQ109 for treating tuberculosis: a multi-arm, multi-stage randomised controlled trial

Martin J. Boeree, Norbert Heinrich, Rob E. Aarnoutse et al. · The Lancet Infectious Diseases · 2016 · 385 citations · Full text

Pharmacy, Pharmacology, Pharmacotherapy +13

Adding abiraterone or docetaxel to long-term hormone therapy for prostate cancer: directly randomised data from the STAMPEDE multi-arm, multi-stage platform protocol

Matthew R. Sydes, Melissa Spears, Malcolm D. Mason et al. · Annals of Oncology · 2018 · 250 citations · Full text

Medicine, Oncology, Urology +17

HIV self-testing alone or with additional interventions, including financial incentives, and linkage to care or prevention among male partners of antenatal care clinic attendees in Malawi: An adaptive multi-arm, multi-stage cluster randomised trial

Augustine Choko, Elizabeth L. Corbett, Nigel Stallard et al. · PLoS Medicine · 2019 · 212 citations · Full text

Public Health, Community Health, Maternal Health +17

Flexible trial design in practice - stopping arms for lack-of-benefit and adding research arms mid-trial in STAMPEDE: a multi-arm multi-stage randomized controlled trial

Matthew R. Sydes, Mahesh Parmar, Malcolm D. Mason et al. · Trials · 2012 · 173 citations · Full text

Medicine, Oncology, Cancer Control +16

1–5 of 51

Authors

350

MP
Mahesh Parmar
University College London, United Kingdom
22 publications · 1.7K citations
19
h-index
MR
Matthew R. Sydes
MRC Clinical Trials Unit at UCL, United Kingdom
14 publications · 1.6K citations
13
h-index
ND
Nicholas D. James
University of Birmingham, United Kingdom
12 publications · 1.6K citations
12
h-index
DP
David P. Dearnaley
Institute of Cancer Research, United Kingdom
9 publications · 1.3K citations
9
h-index
TJ
Thomas Jaki
Lancaster University, United Kingdom
9 publications · 586 citations
9
h-index

1–5 of 350

Institutions

186

1–8 of 186

Venues

Trials
9 publications · 496 citations
9
h-index
Statistics in Medicine
6 publications · 314 citations
6
h-index
Clinical Trials
4 publications · 164 citations
4
h-index
BMC Medical Research Methodology
3 publications · 78 citations
3
h-index
Statistical Methods in Medical Research
2 publications · 173 citations
2
h-index

1–5