Clinical Trials

An exploratory test for an excess of significant findings

John P. A. Ioannidis, Thomas A Trikalinos · 2007 · 789 citations

Public Health, Biostatistics, Psychiatry +17

The design and rationale of a multicenter clinical trial comparing two strategies for control of systolic blood pressure: The Systolic Blood Pressure Intervention Trial (SPRINT)

Walter T. Ambrosius, Kaycee M. Sink, Capri G. Foy et al. · 2014 · 546 citations · Full text

Medicine, Cardiology, Clinical Pharmacology +12

Beyond the intention-to-treat in comparative effectiveness research

Miguel A. Hernán, Sonia Hernández–Dı́az · 2011 · 527 citations · Full text

Pharmacy, Biostatistics, Causal Inference +16

Key cost drivers of pharmaceutical clinical trials in the United States

Aylin Sertkaya, Hui–Hsing Wong, Amber Jessup et al. · 2016 · 411 citations

Pharmacy, Pharmaceutical Policy, Pharmacoeconomics +14

Unsuccessful trial accrual and human subjects protections: An empirical analysis of recently closed trials

Benjamin Gregory Carlisle, Jonathan Kimmelman, Tim Ramsay et al. · 2014 · 387 citations

Public Health, Public Health Ethics, Evidence-based Practice +15