Albumin-based nanoconjugates for targeted delivery of therapeutic oligonucleotides

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

Yasuhiro Matsumura, Hiroshi Maeda · PubMed · 1986 · 6.8K citations

Medicine, Oncology, Pharmacology +12

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

Mark E. Davis, Jonathan E. Zuckerman, Chung Hang Jonathan Choi et al. · Nature · 2010 · 2.5K citations · Full text

Pharmacy, Molecular Pharmaceutics, Pharmacology +12

Spheroid-based drug screen: considerations and practical approach

Juergen Friedrich, Claudia Seidel, Reinhard Ebner et al. · Nature Protocols · 2009 · 1.7K citations

Medicine, Pharmacology, Drug Discovery +3

Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: an open-label, phase 2, dose-escalation study

Sebahattin Çirak, Virginia Arechavala‐Gomeza, Michela Guglieri et al. · The Lancet · 2011 · 862 citations · Full text

Medicine, Neurology, Pharmacotherapy +13

Size-Dependent Localization and Penetration of Ultrasmall Gold Nanoparticles in Cancer Cells, Multicellular Spheroids, and Tumors <i>in Vivo</i>

Keyang Huang, Huili Ma, Juan Liu et al. · ACS Nano · 2012 · 827 citations

Pharmacy, Cancer Biology, Oncology +17