Identification of Small-Molecule Inhibitors of RGS4 Using a High-Throughput Flow Cytometry Protein Interaction Assay

Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain.

Paul C. Sternweis, Janet D. Robishaw · Journal of Biological Chemistry · 1984 · 1.3K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +10

Development and optimization of a binding assay for the XIAP BIR3 domain using fluorescence polarization

Zaneta Nikolovska‐Coleska, Renxiao Wang, Xueliang Fang et al. · Analytical Biochemistry · 2004 · 557 citations

Life Sciences, Biochemistry, Molecular Biology +15

Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

Alexei Degterev, Alexey A. Lugovskoy, Michael H. Cardone et al. · Nature Cell Biology · 2001 · 547 citations

Pharmacy, Medicinal Chemistry, Molecular Biology +11

Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia

Károly Mirnics, Frank A. Middleton, Gregg D. Stanwood et al. · Molecular Psychiatry · 2001 · 447 citations

Life Sciences, Neurobiology, Neuroscience +11

RGS4 and GAIP are GTPase-activating proteins for G _qα and block activation of phospholipase Cβ by γ-thio-GTP-G _qα

John R. Hepler, David M. Berman, Alfred G. Gilman et al. · Proceedings of the National Academy of Sciences · 1997 · 366 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14