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Novel pyrazolo[1,5-a]pyridines as p110α-selective PI3 kinase inhibitors: Exploring the benzenesulfonohydrazide SAR

Jackie D. Kendall, Anna C. Giddens, Kit Yee Tsang, Raphaël Frédérick, Elaine S. Marshall, Ripudaman Singh, Claire L. Lill, Woo Jung Lee, Sharada Kolekar, Mindy Chao,

Bioorganic & Medicinal Chemistry · 2011 · 36 citations · 13 references

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13

A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling

Zachary A. Knight, Beatriz González, Morri E. Feldman et al. · Cell · 2006 · 1.2K citations · Full text

, , +14

Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling

Claire Chaussade, Gordon W. Rewcastle, Jackie D. Kendall et al. · Biochemical Journal · 2007 · 227 citations · Full text

, , +16

A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types

Stephen M. F. Jamieson, Jack U. Flanagan, Sharada Kolekar et al. · Biochemical Journal · 2011 · 172 citations · Full text

, , +14

Cancer-derived mutations in the regulatory subunit p85α of phosphoinositide 3-kinase function through the catalytic subunit p110α

Minghao Sun, Petra Hillmann, Bianca T. Hofmann et al. · Proceedings of the National Academy of Sciences · 2010 · 156 citations · Full text

, , +17

Synthesis and biological evaluation of imidazo[1,2-a]pyridine derivatives as novel PI3 kinase p110α inhibitors

Masahiko Hayakawa, Hiroyuki Kaizawa, Kenichi Kawaguchi et al. · Bioorganic & Medicinal Chemistry · 2006 · 124 citations · Full text

, , +10