Activation of caspase-3 and cleavage of Rb are associated with p16-mediated apoptosis in human non-small cell lung cancer cells

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

Donald W. Nicholson, Ambereen Ali, Nancy A. Thornberry et al. · Nature · 1995 · 4K citations

Life Sciences, Cell Biology, Molecular Biology +13

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

Jamil Momand, Gerard P. Zambetti, David C. Olson et al. · Cell · 1992 · 3.1K citations

Medicine, Molecular Biology, Oncology +10

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

Yuri Lazebnik, Scott H. Kaufmann, Serge Desnoyers et al. · Nature · 1994 · 2.6K citations

Life Sciences, Biochemistry, Molecular Biology +10

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

Muneesh Tewari, Long T. Quan, Karen O’Rourke et al. · Cell · 1995 · 2.4K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +15

Effects of an Rb mutation in the mouse

Tyler Jacks, Amin Fazeli, Earlene M. Schmitt et al. · Nature · 1992 · 1.8K citations

Medicine, Genetics, Molecular Genetics +11