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Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity

Pancreatic CancerOncogenic AgentApoptosisNrf2 Transcription FactorPathologyCell DeathTumor SuppressorProteasomal Gene ExpressionMedicineCell BiologyTumor MicroenvironmentCancer ResearchProteasome Activity