Concepedia

Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity

Alexander Arlt, Susanne Sebens, Stefan Krebs, Claudia Geismann, M-L Kruse, Stefan Schreiber, H. Schäfer

Oncogene · 2012 · 327 citations · 48 references

DOI

Concepts

References

48

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

Gina M. DeNicola, Florian A. Karreth, Timothy J. Humpton et al. · Nature · 2011 · 2.2K citations · Full text

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Dysfunctional KEAP1–NRF2 Interaction in Non-Small-Cell Lung Cancer

Anju Singh, Vikas Misra, Rajesh K. Thimmulappa et al. · PLoS Medicine · 2006 · 1K citations · Full text

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Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

X.-J. Wang, Zheng Sun, Nicole Villeneuve et al. · Carcinogenesis · 2008 · 842 citations · Full text

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Modulation of Gene Expression by Cancer Chemopreventive Dithiolethiones through the Keap1-Nrf2 Pathway

Mi-Kyoung Kwak, Nobunao Wakabayashi, Ken Itoh et al. · Journal of Biological Chemistry · 2003 · 655 citations · Full text

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Enhanced Expression of the Transcription Factor Nrf2 by Cancer Chemopreventive Agents: Role of Antioxidant Response Element-Like Sequences in the <i>nrf2</i> Promoter

Mi-Kyoung Kwak, Ken Itoh, Masayuki Yamamoto et al. · Molecular and Cellular Biology · 2002 · 586 citations · Full text

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