Concepedia

Diminished toxicity of C-1748, 4-methyl-9-hydroxyethylamino-1-nitroacridine, compared with its demethyl analog, C-857, corresponds to its resistance to metabolism in HepG2 cells

Anita Wiśniewska, Magdalena Niemira, Karolina Jagiełło, Agnieszka Potęga, Małgorzata Świst, Colin J. Henderson, Anna Skwarska, Ewa Augustin, Jerzy Konopa, Zofia Mazerska

Biochemical Pharmacology · 2012 · 11 citations · 22 references

DOI

Concepts

References

22

Inactivation of the Hepatic Cytochrome P450 System by Conditional Deletion of Hepatic Cytochrome P450 Reductase

Colin J. Henderson, Diana M. E. Otto, Mark A. Magnuson et al. · Journal of Biological Chemistry · 2003 · 260 citations · Full text

, , +10

Selective toxicity of nitracrine to hypoxic mammalian cells

William R. Wilson, William A. Denny, Simon J. Twigden et al. · British Journal of Cancer · 1984 · 78 citations

, , +5

Bystander Effects of Bioreductive Drugs: Potential for Exploiting Pathological Tumor Hypoxia with Dinitrobenzamide Mustards

William R. Wilson, Kevin O. Hicks, Susan M. Pullen et al. · Radiation Research · 2007 · 75 citations

, , +17

Drug-metabolising enzymes are down-regulated by hypoxia in differentiated human hepatoma HepaRG cells: HIF-1α involvement in CYP3A4 repression

Claire Legendre, Tamaki Hori, Pascal Loyer et al. · European Journal of Cancer · 2009 · 67 citations

, , +17

Hypoxia-selective antitumor agents. 1. Relationships between structure, redox properties and hypoxia-selective cytotoxicity for 4-substituted derivatives of nitracrine

William Wilson, Robert F. Anderson, William A. Denny · Journal of Medicinal Chemistry · 1989 · 64 citations

, , +8