Mechanism of Action and Preclinical Antitumor Activity of the Novel Hypoxia-Activated DNA Cross-Linking Agent PR-104

Adam V. Patterson, Dianne M. Ferry, Shelley J. Edmunds, +10

Clinical Cancer Research

2-Amino metabolites are key mediators of CB 1954 and SN 23862 bystander effects in nitroreductase GDEPT

Nuala A. Helsby, D.M. Ferry, Adam V. Patterson, +2

British Journal of Cancer

Hypoxia-selective antitumor agents. 3. Relationships between structure and cytotoxicity against cultured tumor cells for substituted N,N-bis(2-chloroethyl)anilines

Brian D. Palmer, William Wilson, Susan M. Pullen, +1

Journal of Medicinal Chemistry

DNA Cross-Links in Human Tumor Cells Exposed to the Prodrug PR-104A: Relationships to Hypoxia, Bioreductive Metabolism, and Cytotoxicity

Rachelle S. Singleton, Christopher P. Guise, Dianne M. Ferry, +5

Cancer Research

Chemoprevention StrategyTumor Growth DelayRedox BiologyTumor BiologyToxicological Mechanism +22

Quantitation of bystander effects in nitroreductase suicide gene therapy using three-dimensional cell cultures.

William R. Wilson, Susan M. Pullen, Alison Hogg, +3

PubMed

EngineeringCell DeathMultilayer ModelThree-dimensional Cell CulturesDrug Resistance +15

Bystander Effects of Bioreductive Drugs: Potential for Exploiting Pathological Tumor Hypoxia with Dinitrobenzamide Mustards

William R. Wilson, Kevin O. Hicks, Susan M. Pullen, +3

Radiation Research

PharmacotherapySevere HypoxiaRedox BiologyTumor BiologyOxidative Stress +20

Unsymmetrical DNA Cross-Linking Agents:  Combination of the CBI and PBD Pharmacophores

Moana Tercel, Stephen M. Stribbling, Hilary M. Sheppard, +6

Journal of Medicinal Chemistry

Drug TargetMolecular BiologyPbd PharmacophoresChemical BiologyPharmaceutical Chemistry +16

DNA Strand Cleavage by the Phenazine Di-<i>N</i>-oxide Natural Product Myxin under Both Aerobic and Anaerobic Conditions

Goutam Chowdhury, Ujjal Sarkar, Susan M. Pullen, +4

Chemical Research in Toxicology

Anaerobic ConditionsMolecular BiologyRedox BiologyOxidative StressReactive Nitrogen Specie +16

Dual Targeting of Hypoxia and Homologous Recombination Repair Dysfunction in Triple-Negative Breast Cancer

Francis W. Hunter, Huai‐Ling Hsu, Jiechuang Su, +3

Molecular Cancer Therapeutics

Breast OncologyChemoprevention StrategyCancer BiologyTumor BiologyDual Targeting +14

A novel fluorometric assay for aldo-keto reductase 1C3 predicts metabolic activation of the nitrogen mustard prodrug PR-104A in human leukaemia cells

Stephen M. F. Jamieson, Yongchuan Gu, Donya Moradi Manesh, +14

Biochemical Pharmacology

Aldo-keto ReductaseBiochemistryMedicineAldo-keto Reductase 1C3Novel Fluorometric Assay +7