Susan M. Pullen

Mechanism of Action and Preclinical Antitumor Activity of the Novel Hypoxia-Activated DNA Cross-Linking Agent PR-104

Adam V. Patterson, Dianne M. Ferry, Shelley J. Edmunds et al. · Clinical Cancer Research · 2007 · 247 citations · Full text

Medicine, Oncology, Pharmacology +16

2-Amino metabolites are key mediators of CB 1954 and SN 23862 bystander effects in nitroreductase GDEPT

Nuala A. Helsby, D.M. Ferry, Adam V. Patterson et al. · British Journal of Cancer · 2004 · 94 citations · Full text

Medicine, Oncology, Pharmacology +14

Hypoxia-selective antitumor agents. 3. Relationships between structure and cytotoxicity against cultured tumor cells for substituted N,N-bis(2-chloroethyl)anilines

Brian D. Palmer, William Wilson, Susan M. Pullen et al. · Journal of Medicinal Chemistry · 1990 · 88 citations

Medicine, Oncology, Pharmacology +6

DNA Cross-Links in Human Tumor Cells Exposed to the Prodrug PR-104A: Relationships to Hypoxia, Bioreductive Metabolism, and Cytotoxicity

Rachelle S. Singleton, Christopher P. Guise, Dianne M. Ferry et al. · Cancer Research · 2009 · 83 citations · Full text

Medicine, Pharmacology, Toxicology +15

Quantitation of bystander effects in nitroreductase suicide gene therapy using three-dimensional cell cultures.

William R. Wilson, Susan M. Pullen, Alison Hogg et al. · PubMed · 2002 · 81 citations

Medicine, Biotechnology, Cancer Biology +13