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Synthesis and Biological Evaluation of 2-Indolyloxazolines as a New Class of Tubulin Polymerization Inhibitors. Discovery of A-289099 as an Orally Active Antitumor Agent

Medicinal ChemistryBiochemistryMedicineNatural SciencesTubulin Polymerization InhibitorsNew ClassPharmacotherapyBiological EvaluationAnti-cancer AgentDrug DevelopmentChemical BiologyPharmacologyPharmaceutical ChemistryInhibitory ActivityDrug Discovery