Isoxazolines and isoxazoles as factor Xa inhibitors

Structure of Human Des(1-45) Factor Xa at 2·2 Å Resolution

K. Padmanabhan, K. Padmanabhan, A. Tulinsky et al. · Journal of Molecular Biology · 1993 · 391 citations

X-ray Crystallography, Human Des, Natural Sciences +5

A particularly convenient preparation of benzohydroximinoyl chlorides (nitrile oxide precursors)

Kou-Chang Liu, Becky R. Shelton, Robert K. Howe · The Journal of Organic Chemistry · 1980 · 362 citations

Inorganic Chemistry, Chemical Engineering, Engineering +11

Conjunctive enhancement of enzymatic thrombolysis and prevention of thrombotic reocclusion with the selective factor Xa inhibitor, tick anticoagulant peptide. Comparison to hirudin and heparin in a canine model of acute coronary artery thrombosis.

Gary R. Sitko, Denise Ramjit, Inez I. Stabilito et al. · Circulation · 1992 · 131 citations · Full text

A Novel Asymmetric Route to Chiral, Nonracemic cis-2,6-Disubstituted Piperidines. Synthesis of (+)-Pinidinone and (+)-Monomorine

Michael J. Munchhof, A. I. MEYERS · Journal of the American Chemical Society · 1995 · 87 citations

Combinatorial Chemistry, Engineering, Donut Icon +13

Design and Synthesis of Isoxazoline Derivatives as Factor Xa Inhibitors. 1

Mimi L. Quan, Ann Y. Liauw, Christopher D. Ellis et al. · Journal of Medicinal Chemistry · 1999 · 80 citations · Full text