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Structure based design of novel 6,5 heterobicyclic mitogen-activated protein kinase kinase (MEK) inhibitors leading to the discovery of imidazo[1,5-a] pyrazine G-479

Combinatorial ChemistryMedicinal ChemistryBiochemistryNatural SciencesMedicineRational Drug DesignNovel 6,5Drug DevelopmentChemical BiologyPharmacologyPharmaceutical ChemistryDrug Discovery