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Tyrosine Phosphorylation Controls Internalization of CTLA-4 by Regulating Its Interaction with Clathrin-Associated Adaptor Complex AP-2

Tooru Shiratori, Shoichiro Miyatake, Hiroshi Ohno, Chiaki Nakaseko, Kaichi Isono, Juan S. Bonifacino, Takashi Saito

Immunity · 1997 · 343 citations · 14 references

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14

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

Elizabeth Tivol, Frank Borriello, Alain Schweitzer et al. · Immunity · 1995 · 2.9K citations · Full text

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CTLA-4 can function as a negative regulator of T cell activation

Theresa L. Walunas, Deborah J. Lenschow, Christina Y. Bakker et al. · Immunity · 1994 · 2.2K citations

, , +14

CTLA-4 is a second receptor for the B cell activation antigen B7.

Peter S. Linsley, William Brady, M Urnes et al. · The Journal of Experimental Medicine · 1991 · 1.7K citations · Full text

, , +17

A new member of the immunoglobulin superfamily—CTLA-4

Jean‐François Brunet, François Denizot, Marie‐Françoise Luciani et al. · Nature · 1987 · 1.3K citations

, , +11

Interaction of Tyrosine-Based Sorting Signals with Clathrin-Associated Proteins

Hiroshi Ohno, Jay M. Stewart, Marie-Christine Fournier et al. · Science · 1995 · 966 citations

, , +17