Synthesis of the first example of a c2-C3/C2′-C3′-endo unsaturated pyrrolo[2,1-c][1,4]benzodiazepine dimer

Design, Synthesis, and Evaluation of a Novel Pyrrolobenzodiazepine DNA-Interactive Agent with Highly Efficient Cross-Linking Ability and Potent Cytotoxicity

Stephen J. Gregson, Philip W. Howard, John A. Hartley et al. · Journal of Medicinal Chemistry · 2001 · 200 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Rational design of a highly efficient irreversible DNA interstrand cross-linking agent based on the pyrrolobenzodiazepine ring system

D. Subhas Bose, Andrew S. Thompson, Jingshan Ching et al. · Journal of the American Chemical Society · 1992 · 136 citations

Pharmacy, Medicinal Chemistry, Bioorthogonal Chemistry +8

A novel trans-platinum coordination complex possessing in vitro and in vivo antitumor activity.

Lloyd R. Kèlland, C. F. J. Barnard, Kirste Mellish et al. · PubMed · 1994 · 129 citations

Pharmacy, Medicinal Chemistry, Pharmacology +5

Synthesis of Sequence-Selective C8-Linked Pyrrolo[2,1-<i>c</i>][1,4]benzodiazepine DNA Interstrand Cross-Linking Agents

David E. Thurston, D. Subhas Bose, Andrew S. Thompson et al. · The Journal of Organic Chemistry · 1996 · 114 citations

Pharmacy, Chemistry, Medicinal Chemistry +11

Total synthesis of anthramycin

W. Leimgruber, Andrew D. Batcho, Rafał Czajkowski · Journal of the American Chemical Society · 1968 · 92 citations

Pharmacy, Medicinal Chemistry, Drug Design +6