Concepedia

Characterization of Human Organic Cation Transporter 1 (OCT1/SLC22A1)- and OCT2 (SLC22A2)-Mediated Transport of 1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)- 4,9-dihydro-1H-naphtho[2,3-d]imidazolium Bromide (YM155 Monobromide), a Novel Small Molecule Survivin Suppressant

Tsuyoshi Minematsu, Megumi Iwai, Kenichi Umehara, Takashi Usui, Hidetaka Kamimura

Drug Metabolism and Disposition · 2009 · 57 citations · 11 references

DOI

Concepts

References

11

A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma

Grazia Ambrosini, Colette Adida, Dario C. Altieri · Nature Medicine · 1997 · 3.2K citations

, , +12

Regulation of apoptosis at cell division by p34 <sup>cdc2</sup> phosphorylation of survivin

Daniel O’Connor, Douglas Grossman, Janet Plescia et al. · Proceedings of the National Academy of Sciences · 2000 · 614 citations · Full text

, , +17

YM155, a Novel Small-Molecule Survivin Suppressant, Induces Regression of Established Human Hormone-Refractory Prostate Tumor Xenografts

Takahito Nakahara, Masahiro Takeuchi, Isao Kinoyama et al. · Cancer Research · 2007 · 506 citations

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Effect of Genetic Variation in the Organic Cation Transporter 1, OCT1, on Metformin Pharmacokinetics

C. Randell Brown, R A Castro, RJ Shi et al. · Clinical Pharmacology & Therapeutics · 2007 · 467 citations

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Genetic Variants of the Organic Cation Transporter 2 Influence the Disposition of Metformin

Song Is, Shin Hj, EJ Shim et al. · Clinical Pharmacology & Therapeutics · 2008 · 267 citations

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