Tsuyoshi Minematsu

YM155, a Novel Small-Molecule Survivin Suppressant, Induces Regression of Established Human Hormone-Refractory Prostate Tumor Xenografts

Takahito Nakahara, Masahiro Takeuchi, Isao Kinoyama et al. · Cancer Research · 2007 · 506 citations

Medicine, Oncology, Pharmacology +17

Interactions of Tyrosine Kinase Inhibitors with Organic Cation Transporters and Multidrug and Toxic Compound Extrusion Proteins

Tsuyoshi Minematsu, Kathleen M. Giacomini · Molecular Cancer Therapeutics · 2011 · 196 citations

Medicine, Pharmacokinetics, Pharmacology +17

Characterization of Human Organic Cation Transporter 1 (OCT1/SLC22A1)- and OCT2 (SLC22A2)-Mediated Transport of 1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)- 4,9-dihydro-1H-naphtho[2,3-d]imidazolium Bromide (YM155 Monobromide), a Novel Small Molecule Survivin Suppressant

Tsuyoshi Minematsu, Megumi Iwai, Kenichi Umehara et al. · Drug Metabolism and Disposition · 2009 · 57 citations

Medicine, Oncology, Pharmacology +10

Utility of P-Glycoprotein and Organic Cation Transporter 1 Double-Transfected LLC-PK1 Cells for Studying the Interaction of YM155 Monobromide, Novel Small-Molecule Survivin Suppressant, with P-Glycoprotein

Megumi Iwai, Tsuyoshi Minematsu, Qun Li et al. · Drug Metabolism and Disposition · 2011 · 51 citations

Medicine, Medicinal Chemistry, Pharmacology +17

Quantitative Relationship Between Myocardial Concentration of Tacrolimus and QT Prolongation in Guinea Pigs: Pharmacokinetic/Pharmacodynamic Model Incorporating a Site of Adverse Effect

Tsuyoshi Minematsu, Hisakazu Ohtani, Yasuhiko Yamada et al. · Journal of Pharmacokinetics and Pharmacodynamics · 2001 · 49 citations

Pharmacy, Pharmacokinetics, Pharmacology +13