Concepedia

Blood–brain barrier transport of synthetic adenosine A1 receptor agonists in vitro: structure transport relationships

Marloes Schaddelee, Heleen L. Voorwinden, Dorien Groenendaal, Anne Hersey, Adriaan P. IJzerman, Meindert Danhof, Albertus G. de Boer

European Journal of Pharmaceutical Sciences · 2003 · 16 citations · 34 references

DOI

Concepts

References

34

Astrocytes induce blood–brain barrier properties in endothelial cells

Robert C. Janzer, Martin Raff · Nature · 1987 · 1.6K citations

, , +14

Polar Molecular Surface as a Dominating Determinant for Oral Absorption and Brain Penetration of Drugs

J. Kelder, Peter D. J. Grootenhuis, Denis M. Bayada et al. · Pharmaceutical Research · 1999 · 799 citations

, , +13

Turnover of adenosine in plasma of human and dog blood

Georg Möser, Jürgen Schrader · American Journal of Physiology-Cell Physiology · 1989 · 526 citations

, , +11

Development of a new physicochemical model for brain penetration and its application to the design of centrally acting H2 receptor histamine antagonists

Rodney C. Young, Robert Cameron Mitchell, Thomas H. Brown et al. · Journal of Medicinal Chemistry · 1988 · 522 citations

, , +15

Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 2. Prediction of blood–brain barrier penetration

David E. Clark · Journal of Pharmaceutical Sciences · 1999 · 516 citations

, , +16