Dorien Groenendaal

Population pharmacokinetic modelling of non‐linear brain distribution of morphine: influence of active saturable influx and P‐glycoprotein mediated efflux

Dorien Groenendaal, Jan Freijer, D de Mik et al. · British Journal of Pharmacology · 2007 · 63 citations · Full text

High-performance liquid chromatography of nalbuphine, butorphanol and morphine in blood and brain microdialysate samples: Application to pharmacokinetic/pharmacodynamic studies in rats

Dorien Groenendaal, Margret C.M. Blom-Roosemalen, Meindert Danhof et al. · Journal of Chromatography B · 2005 · 39 citations

Medicine, High-performance Liquid Chromatography, Brain Microdialysate Samples +7

Pharmacokinetic/pharmacodynamic modelling of the EEG effects of opioids: The role of complex biophase distribution kinetics

Dorien Groenendaal, Jan Freijer, Andrea Rosier et al. · European Journal of Pharmaceutical Sciences · 2008 · 32 citations

Physiologically-based Pharmacokinetic Modeling, Neurophysiology, Computational Neuroscience +15

Influence of biophase distribution and P‐glycoprotein interaction on pharmacokinetic‐pharmacodynamic modelling of the effects of morphine on the EEG

Dorien Groenendaal, Jan Freijer, D de Mik et al. · British Journal of Pharmacology · 2007 · 24 citations · Full text

Absorption, metabolism and excretion of darexaban (YM150), a new direct factor Xa inhibitor in humans

Tadashi Hashimoto, Katsuhiro Suzuki, Yukie Kihara et al. · Xenobiotica · 2012 · 15 citations

Darexaban Glucuronide, Pharmacotherapy, Experimental Pharmacology +21