Concepedia

1,5-Biaryl pyrrole derivatives as EP1 receptor antagonists: Structure–activity relationships of 4- and 5-substituted benzoic acid derivatives

Adrian Hall, Susan H. Brown, Iain P. Chessell, A. R. Chowdhury, Nicholas M. Clayton, Tanya Coleman, Gerard M.P. Giblin, Beverley Hammond, Mark P. Healy, Matthew R. Johnson,

Bioorganic & Medicinal Chemistry Letters · 2006 · 12 citations · 7 references

DOIFull text

Open access

Concepts

References

7

Comprehensive medicinal chemistry

H. Timmerman, Aalt Bast, H. van der Goot et al. · Trends in Pharmacological Sciences · 1991 · 1.2K citations

The prostaglandin E2 EP1 receptor mediates pain perception and regulates blood pressure

Jeffrey L. Stock, Katsuhiro Shinjo, John Burkhardt et al. · Journal of Clinical Investigation · 2001 · 237 citations · Full text

, , +17

A Prostaglandin E2 Receptor Subtype EP1 Receptor Antagonist (ONO-8711) Reduces Hyperalgesia, Allodynia, and C-fos Gene Expression in Rats with Chronic Nerve Constriction

Hiroyasu Kawahara, Atsuhiro Sakamoto, Shinhiro Takeda et al. · Anesthesia & Analgesia · 2001 · 55 citations

, , +14

The Effects of Peripheral Administration of a Novel Selective Antagonist for Prostaglandin E Receptor Subtype EP1, ONO-8711, in a Rat Model of Postoperative Pain

Keiichi Omote, Tomoyuki Kawamata, Yoshito Nakayama et al. · Anesthesia & Analgesia · 2001 · 50 citations

, , +17

The Effects of Intrathecal Administration of an Antagonist for Prostaglandin E Receptor Subtype EP1 on Mechanical and Thermal Hyperalgesia in a Rat Model of Postoperative Pain

Keiichi Omote, Hiroki Yamamoto, Tomoyuki Kawamata et al. · Anesthesia & Analgesia · 2002 · 38 citations

, , +16