Nicholas M. Clayton

Non-acidic pyrazole EP1 receptor antagonists with in vivo analgesic efficacy

Adrian Hall, Andy Billinton, Susan H. Brown et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 76 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

The discovery of 6-[2-(5-chloro-2-{[(2,4-difluorophenyl)methyl]oxy}phenyl)-1-cyclopenten-1-yl]-2-pyridinecarboxylic acid, GW848687X, a potent and selective prostaglandin EP1 receptor antagonist for the treatment of inflammatory pain

Gerard M.P. Giblin, Rino A. Bit, Susan H. Brown et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 47 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

Structure–activity relationships of 1,5-biaryl pyrroles as EP1 receptor antagonists

Adrian Hall, Stephen J. Atkinson, Susan H. Brown et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 32 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +12

Discovery of GSK345931A: An EP1 receptor antagonist with efficacy in preclinical models of inflammatory pain

Adrian Hall, Susan H. Brown, Nicholas M. Clayton et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 27 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15

Discovery of sodium 6-[(5-chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)methyl]-2-pyridinecarboxylate (GSK269984A) an EP1 receptor antagonist for the treatment of inflammatory pain

Adrian Hall, Andy Billinton, Susan H. Brown et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 19 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14