Concepedia

Discovery of sodium 6-[(5-chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)methyl]-2-pyridinecarboxylate (GSK269984A) an EP1 receptor antagonist for the treatment of inflammatory pain

Adrian Hall, Andy Billinton, Susan H. Brown, A. R. Chowdhury, Nicholas M. Clayton, Gerard M.P. Giblin, Mairi Gibson, Paul Goldsmith, David N. Hurst, Alan Naylor,

Bioorganic & Medicinal Chemistry Letters · 2009 · 19 citations · 37 references

DOIFull text

Open access

Concepts

References

37

SOME QUANTITATIVE USES OF DRUG ANTAGONISTS

O. ARUNLAKSHANA, H. O. Schild · British Journal of Pharmacology and Chemotherapy · 1959 · 4K citations · Full text

, , +16

Comprehensive medicinal chemistry

H. Timmerman, Aalt Bast, H. van der Goot et al. · Trends in Pharmacological Sciences · 1991 · 1.2K citations

Highly Functionalized Organomagnesium Reagents Prepared through Halogen–Metal Exchange

Paul Knochel, Wolfgang Döhle, Nina Gommermann et al. · Angewandte Chemie International Edition · 2003 · 770 citations

, , +12

Synthesis and reactivity toward acyl chlorides and enones of the new highly functionalized copper reagents RCu(CN)ZnI

Paul Knochel, M.-C.P. Yeh, Scott C. Berk et al. · The Journal of Organic Chemistry · 1988 · 688 citations

, , +8

Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase

Catherine E. Trebino, Jeffrey L. Stock, Colleen P. Gibbons et al. · Proceedings of the National Academy of Sciences · 2003 · 547 citations · Full text

, , +17