Comprehensive medicinal chemistry

H. Timmerman, Aalt Bast, H. van der Goot, +2

Trends in Pharmacological Sciences

Medicinal ChemistryActive IngredientNatural SciencesMedicineComprehensive Medicinal Chemistry +4

Abstract of papers

Antonius W.T. Konings, H. Joenje, Aalt Bast, +104

Pharmacy World & Science

Document EngineeringAbstract Object TheoryAbstract Analysis

Inverse agonism of histamine H2 antagonist accounts for upregulation of spontaneously active histamine H2 receptors.

Martine J. Smit, Rob Leurs, A. E. Alewijnse, +5

Proceedings of the National Academy of Sciences

Molecular PharmacologyHistamine H2 ReceptorSignal TransductionAllergyFunctional Selectivity +12

Inhibition of cortical acetylcholine release and cognitive performance by histamine H₃ receptor activation in rats

Patrizio Blandina, Marco Giorgetti, L. Bartolini, +5

British Journal of Pharmacology

Synthesis of some symmetrical curcumin derivatives and their antiinflammatory activity

A.N. Nurfina, M.S. Reksohadiprodjo, H. Timmerman, +3

European Journal of Medicinal Chemistry

Medicinal ChemistryDerivative (Chemistry)DerivativesNatural SciencesSymmetrical Curcumin Derivatives +4

Lipophilicity and hydrogen-bonding capacity of H1-antihistaminic agents in relation to their central sedative side-effects

Antonius ter Laak, R.‐S. TSAI, Gabriëlle M. Donné-Op den Kelder, +3

European Journal of Pharmaceutical Sciences

BiochemistryHydrogen-bonding CapacityMedicineAntiparasitic AgentPharmacology +8

A New Potent and Selective Histamine H3 Receptor Agonist, 4-(1H-imidazol-4-ylmethyl)piperidine

Roeland C. Vollinga, J. de Koning, Frank Jansen, +3

Journal of Medicinal Chemistry

Altmetric Attention ScorePharmacotherapySystem PharmacologyPharmaceutical ChemistryPre-clinical Pharmacology +21

Site-Directed Mutagenesis of the Histamine H1-Receptor Reveals a Selective Interaction of Asparagine207 with Subclasses of H1-Receptor Agonists

Rob Leurs, Martine J. Smit, Cornelis P. Tensen, +1

Biochemical and Biophysical Research Communications

Drug TargetSignal TransductionFunctional SelectivityMedicineG Protein-coupled Receptor +8

Effects of histamine H₁‐, H₂‐ and H₃‐receptor selective drugs on the mechanical activity of guinea‐pig small and large intestine

R. Leurs, Marion M. Brozius, Martine J. Smit, +2

British Journal of Pharmacology

Gastrointestinal PharmacologyGastroenterologyExperimental PharmacologyNeuromuscular BlockadeMolecular Pharmacology +17

Evaluation of the receptor selectivity of the H₃ receptor antagonists, iodophenpropit and thioperamide: an interaction with the 5‐HT₃ receptor revealed

Rob Leurs, M.Th.M. Tulp, Wiro M.B.P. Menge, +3

British Journal of Pharmacology