Rino A. Bit

Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition

Natalie H. Theodoulou, Paul Bamborough, Andrew J. Bannister et al. · Journal of Medicinal Chemistry · 2015 · 234 citations · Full text

Life Sciences, Molecular Biology, Oncology +15

Inhibitors of protein kinase C. 3. Potent and highly selective bisindolylmaleimides by conformational restriction

Rino A. Bit, Peter D. Davis, Lucy H. Elliott et al. · Journal of Medicinal Chemistry · 1993 · 157 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16

Discovery of a Bromodomain and Extraterminal Inhibitor with a Low Predicted Human Dose through Synergistic Use of Encoded Library Technology and Fragment Screening

Christopher R. Wellaway, Dominique Amans, Paul Bamborough et al. · Journal of Medicinal Chemistry · 2020 · 71 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

The discovery of 6-[2-(5-chloro-2-{[(2,4-difluorophenyl)methyl]oxy}phenyl)-1-cyclopenten-1-yl]-2-pyridinecarboxylic acid, GW848687X, a potent and selective prostaglandin EP1 receptor antagonist for the treatment of inflammatory pain

Gerard M.P. Giblin, Rino A. Bit, Susan H. Brown et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 47 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

A mild conversion of maleic anhydrides into maleimides

Peter D. Davis, Rino A. Bit · Tetrahedron Letters · 1990 · 47 citations

Life Sciences, Biochemistry, Chemical Engineering +4