Caspase 3 Inhibition Improves Survival and Reduces Early Graft Injury After Ischemia and Reperfusion in Rat Liver Transplantation

Abstract

Specific inhibition of apoptosis executor caspases effectively reduces graft ischemia-reperfusion injury and improves survival in liver transplantation. Better tissue preservation after caspase inhibition correlates with reduced apoptosis execution, improved microvascular perfusion, and bcl-2 up-regulation. Therefore, specific caspase inhibition represents a promising regimen for clinical use in liver transplantation.