Concepedia

Constrained cycloalkyl analogues of glutamic acid: stereocontrolled synthesis of (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740) and its 6-phosphonic acid analogue

Jerzy A. Krysiak, Wanda H. Midura, Wanda Wieczorek, Lesław Sieroń, M. Mikołajczyk

Tetrahedron Asymmetry · 2010 · 23 citations · 19 references

DOI

Concepts

References

19

Phase annealing in SHELX-90: direct methods for larger structures

George M. Sheldrick · Acta Crystallographica Section A Foundations of Crystallography · 1990 · 16.3K citations

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Design, Synthesis, and Pharmacological Characterization of (+)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY354740):  A Potent, Selective, and Orally Active Group 2 Metabotropic Glutamate Receptor Agonist Possessing Anticonvulsant and Anxiolytic Properties

James A. Monn, Matthew J. Valli, Steven M. Massey et al. · Journal of Medicinal Chemistry · 1997 · 393 citations

, , +17

LY354740 is a Potent and Highly Selective Group II Metabotropic Glutamate Receptor Agonist in Cells Expressing Human Glutamate Receptors

Darryle D. Schoepp, Bryan G. Johnson, Rebecca A. Wright et al. · Neuropharmacology · 1997 · 227 citations

, , +11

Asymmetric synthesis of carbon-carbon bonds using sulfinyl cycloalkenones, alkenolides, and pyrones

Gary H. Posner · Accounts of Chemical Research · 1987 · 171 citations

, , +7

Asymmetric Sulfonium Ylide Mediated Cyclopropanation: Stereocontrolled Synthesis of (+)‐LY354740

Varinder K. Aggarwal, Emma Grange · Chemistry - A European Journal · 2005 · 86 citations

, , +13