Darryle D. Schoepp

Synaptic Activity Regulates Interstitial Fluid Amyloid-β Levels In Vivo

John R. Cirrito, Kelvin A. Yamada, Mary Beth Finn et al. · Neuron · 2005 · 1.3K citations · Full text

Synaptic Plasticity, Neurodegenerative Diseases, Molecular Neuroscience +8

Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial

Sandeep T. Patil, Lu Zhang, Ferenc Martényi et al. · Nature Medicine · 2007 · 1K citations

Psychiatry, Psychotic Disorder, Medicine +12

A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission

Vernon R. J. Clarke, Barbara A. Ballyk, Ken H. Hoo et al. · Nature · 1997 · 415 citations

Synaptic Plasticity, Neurophysiology, Synaptic Transmission +6

Design, Synthesis, and Pharmacological Characterization of (+)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY354740):  A Potent, Selective, and Orally Active Group 2 Metabotropic Glutamate Receptor Agonist Possessing Anticonvulsant and Anxiolytic Properties

James A. Monn, Matthew J. Valli, Steven M. Massey et al. · Journal of Medicinal Chemistry · 1997 · 392 citations

Pharmacological Characterization, Active Group 2, Psychotropic Medication +16

LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors

Anne Kingston, Paul L. Ornstein, Rebecca A. Wright et al. · Neuropharmacology · 1998 · 364 citations

Functional Selectivity, Medicine, Drug Discovery +7