Null Mutations in the Filaggrin Gene (FLG) Determine Major Susceptibility to Early-Onset Atopic Dermatitis that Persists into Adulthood

Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis

Alan D. Irvine, Ana Terron-Kwiatkowski, Yiwei Zhao et al. · Nature Genetics · 2006 · 2.9K citations

Major Predisposing Factor, Common Loss-of-function Variants, Atopic Dermatitis +8

The U.K. Working Party's Diagnostic Criteria for Atopic Dermatitis..

Hywel C Williams, Roderick J. Hay, Corey Archer et al. · British Journal of Dermatology · 1994 · 1.2K citations

Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris

Frances J.D. Smith, Alan D. Irvine, Ana Terron-Kwiatkowski et al. · Nature Genetics · 2006 · 1K citations

Biology, Mendelian Disorder, Genetic Disorder +10

The U.K. Working Party's Diagnostic Criteria for Atopic Dermatitis. III. Independent hospital validation

Hywel C Williams, A.C. Pembroke, Roderick J. Hay · British Journal of Dermatology · 1994 · 912 citations

Asthma, Allergy, Skin Testing +13

The natural course of atopic dermatitis from birth to age 7 years and the association with asthma

Sabina Illi, Erika von Mutius, Susanne Lau et al. · Journal of Allergy and Clinical Immunology · 2004 · 793 citations · Full text