Null Mutations in the Filaggrin Gene (FLG) Determine Major Susceptibility to Early-Onset Atopic Dermatitis that Persists into Adulthood

Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis

Alan D. Irvine, Ana Terron-Kwiatkowski, Yiwei Zhao et al. · Nature Genetics · 2006 · 3K citations

Medicine, Dermatology, Genetics +16

The U.K. Working Party's Diagnostic Criteria for Atopic Dermatitis..

Hywel C Williams, Roderick J. Hay, Corey Archer et al. · British Journal of Dermatology · 1994 · 1.3K citations

Medicine, Dermatology, Pediatrics +17

Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris

Frances J.D. Smith, Alan D. Irvine, Ana Terron-Kwiatkowski et al. · Nature Genetics · 2006 · 1K citations

Life Sciences, Genetics, Molecular Genetics +9

The U.K. Working Party's Diagnostic Criteria for Atopic Dermatitis. III. Independent hospital validation

Hywel C Williams, A.C. Pembroke, Roderick J. Hay · British Journal of Dermatology · 1994 · 930 citations

Medicine, Dermatology, Pediatrics +14

The natural course of atopic dermatitis from birth to age 7 years and the association with asthma

Sabina Illi, Erika von Mutius, Susanne Lau et al. · Journal of Allergy and Clinical Immunology · 2004 · 798 citations · Full text

Medicine, Dermatology, Immunology +16