Concepedia

Filaggrin Function

Filaggrin Function is a biological construct that refers to the role of filaggrin, a structural protein in the epidermis, in mediating keratin filament aggregation, regulating skin barrier integrity, and contributing to natural moisturizing factor production through its proteolytic breakdown, thereby distinguishing it from other epidermal structural proteins by its dual function in mechanical stability and hydration maintenance.

308

Publications

28.3K

Citations

1.6K

Authors

510

Institutions

Publications per year

2017–2026

80

Parents

Publications

308

Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis

Alan D. Irvine, Ana Terron-Kwiatkowski, Yiwei Zhao et al. · Nature Genetics · 2006 · 3K citations

, , +16

Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris

Frances J.D. Smith, Alan D. Irvine, Ana Terron-Kwiatkowski et al. · Nature Genetics · 2006 · 1K citations

, , +9

Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema

Aileen Sandilands, Ana Terron-Kwiatkowski, Peter Hull et al. · Nature Genetics · 2007 · 664 citations

, , +14

Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations

Stephan Weidinger, Thomas Illig, Hansjörg Baurecht et al. · Journal of Allergy and Clinical Immunology · 2006 · 611 citations

, , +17

The Proteins Elafin, Filaggrin, Keratin Intermediate Filaments, Loricrin, and Small Proline-rich Proteins 1 and 2 Are Isodipeptide Cross-linked Components of the Human Epidermal Cornified Cell Envelope

Peter M. Steinert, Lyuben N. Marekov · Journal of Biological Chemistry · 1995 · 511 citations · Full text

, , +11

1–5 of 308

Authors

1.6K

  1. WI
    W.H. Irwin McLean

    University of Dundee, United Kingdom

    32 publications · 10.6K citations

    28

    h-index

  2. JP
    Jacob P. Thyssen

    Gentofte Hospital, Denmark

    24 publications · 778 citations

    19

    h-index

  3. AD
    Alan D. Irvine

    Trinity College Dublin, Ireland

    17 publications · 8K citations

    17

    h-index

  4. JD
    Jeanne Duus Johansen

    Gentofte Hospital, Denmark

    20 publications · 673 citations

    17

    h-index

  5. AL
    Allan Linneberg

    University of Copenhagen, Denmark

    15 publications · 555 citations

    15

    h-index

1–5 of 1.6K

Institutions

510

  1. University of Dundee

    Dundee, United Kingdom

    27 h-index

    135 publications

    60.8K citations

  2. Gentofte Hospital

    Copenhagen, Denmark

    22 h-index

    128 publications

    5.1K citations

  3. University of Washington

    Seattle, United States

    19 h-index

    53 publications

    10K citations

  4. University of Copenhagen

    Copenhagen, Denmark

    17 h-index

    67 publications

    3.3K citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    15 h-index

    76 publications

    6.6K citations

  6. Inserm

    Paris, France

    15 h-index

    86 publications

    6.8K citations

  7. Ninewells Hospital

    Dundee, United Kingdom

    15 h-index

    73 publications

    65.6K citations

  8. Our Lady's Hospital

    Navan, Ireland

    14 h-index

    30 publications

    18.1K citations

1–8 of 510

Venues

  1. Journal of Investigative Dermatology

    JID · 36 publications · 4.7K citations

    31

    h-index

  2. Journal of Allergy and Clinical Immunology

    34 publications · 6.1K citations

    30

    h-index

  3. British Journal of Dermatology

    20 publications · 1.5K citations

    19

    h-index

  4. Contact Dermatitis

    10 publications · 266 citations

    10

    h-index

  5. Experimental Dermatology

    9 publications · 629 citations

    9

    h-index

1–5