W.H. Irwin McLean

Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis

Alan D. Irvine, Ana Terron-Kwiatkowski, Yiwei Zhao et al. · Nature Genetics · 2006 · 3K citations

Medicine, Dermatology, Genetics +16

Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris

Frances J.D. Smith, Alan D. Irvine, Ana Terron-Kwiatkowski et al. · Nature Genetics · 2006 · 1K citations

Life Sciences, Genetics, Molecular Genetics +9

Filaggrin in the frontline: role in skin barrier function and disease

Aileen Sandilands, Calum Sutherland, Alan D. Irvine et al. · Journal of Cell Science · 2009 · 872 citations · Full text

Life Sciences, Dermatology, Genetics +17

Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention

Eric L. Simpson, Joanne R Chalmers, Jon M. Hanifin et al. · Journal of Allergy and Clinical Immunology · 2014 · 718 citations · Full text

Medicine, Dermatology, Pediatrics +17

Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema

Aileen Sandilands, Ana Terron-Kwiatkowski, Peter Hull et al. · Nature Genetics · 2007 · 664 citations

Life Sciences, Genetics, Molecular Genetics +14