Design and validation of an innovative soft-sensor for pharmaceuticals freeze-drying monitoring

A New Approach to Linear Filtering and Prediction Problems

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Natural Sciences, Mathematics, Dynamical Systems +16

Mass and Heat Transfer in Vial Freeze-Drying of Pharmaceuticals: Role of the Vial

Michael J. Pikal, Michael L. Roy, Saroj Shah · Journal of Pharmaceutical Sciences · 1984 · 343 citations

Pharmacy, Food Science, Pharmaceutics +14

Development of simplified models for the freeze-drying process and investigation of the optimal operating conditions

Salvatore Velardi, Antonello Barresi · Process Safety and Environmental Protection · 2008 · 182 citations

Agriculture, Food Science, Food Engineering +15

Evaluation of manometric temperature measurement as a method of monitoring product temperature during lyophilization.

Nathaniel Milton, Michael J. Pikal, Michael L. Roy et al. · PubMed · 1997 · 155 citations

Pharmacy, Food Science, Food Analysis +16

Evaluation of tunable diode laser absorption spectroscopy for in‐process water vapor mass flux measurements during freeze drying

Henning Gieseler, William J. Kessler, Michael L. Finson et al. · Journal of Pharmaceutical Sciences · 2007 · 138 citations

Engineering, Chemical Engineering, Food Science +14