Developing new chemical tools for DNA methyltransferase 1 (DNMT 1): A small-molecule activity-based probe and novel tetrazole-containing inhibitors

Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality

Ellen M. Sletten, Carolyn R. Bertozzi · Angewandte Chemie International Edition · 2009 · 3.1K citations · Full text

Pharmacy, Biochemistry, Molecular Biology +5

A genome-wide analysis of CpG dinucleotides in the human genome distinguishes two distinct classes of promoters

Serge Saxonov, Paul Berg, Douglas L. Brutlag · Proceedings of the National Academy of Sciences · 2006 · 1.4K citations

Life Sciences, Genetics, Molecular Biology +11

Epigenetic Reactivation of Tumor Suppressor Genes by a Novel Small-Molecule Inhibitor of Human DNA Methyltransferases

Bodo Brueckner, Regine García Boy, Paweł Siedlecki et al. · Cancer Research · 2005 · 542 citations

Medicine, Molecular Biology, Oncology +16

Structure of DNMT1-DNA Complex Reveals a Role for Autoinhibition in Maintenance DNA Methylation

Jikui Song, Olga Rechkoblit, Timothy H. Bestor et al. · Science · 2010 · 457 citations · Full text

Life Sciences, Genetics, Molecular Biology +9

Constructing and Exploiting the Fluorescent Protein Paintbox (Nobel Lecture)

Roger Y. Tsien · Angewandte Chemie International Edition · 2009 · 423 citations

Natural Sciences, Biochemistry, Medicinal Chemistry +14