Concepedia

Epigenetic Probes

Epigenetic Probes is a chemical tool compound that selectively modulates epigenetic targets—such as writers, erasers, or readers of post-translational histone modifications or DNA methylation—to enable the functional dissection of epigenetic mechanisms in biological systems.

56

Publications

2.8K

Citations

454

Authors

154

Institutions

Publications per year

2017–2026

34

Parents

Publications

56

Discovery of an in Vivo Chemical Probe of the Lysine Methyltransferases G9a and GLP

Feng Liu, Dalia Baršytė-Lovejoy, Fengling Li et al. · Journal of Medicinal Chemistry · 2013 · 273 citations · Full text

, , +15

Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies

Edurne San José‐Eneriz, Xabier Agirre, Obdulia Rabal et al. · Nature Communications · 2017 · 170 citations · Full text

, , +17

Chemical genomics reveals histone deacetylases are required for core regulatory transcription

Berkley E. Gryder, Lei Wu, Girma M. Woldemichael et al. · Nature Communications · 2019 · 153 citations · Full text

, , +17

A chemical biology toolbox to study protein methyltransferases and epigenetic signaling

Sebastian Scheer, Suzanne Ackloo, Tiago da Silva Medina et al. · Nature Communications · 2018 · 149 citations · Full text

, , +13

Optimization of Activity-Based Probes for Proteomic Profiling of Histone Deacetylase Complexes

Cleo M. Salisbury, Benjamin F. Cravatt · Journal of the American Chemical Society · 2008 · 130 citations

, , +17

1–5 of 56

Authors

454

  1. CA
    C.H. Arrowsmith

    University of Toronto, Canada

    8 publications · 727 citations

    8

    h-index

  2. PE
    Paul E. Brennan

    University of Oxford, United Kingdom

    5 publications · 293 citations

    5

    h-index

  3. OF
    Oleg Fedorov

    University of Oxford, United Kingdom

    5 publications · 344 citations

    5

    h-index

  4. FL
    Fengling Li

    University of Toronto, Canada

    5 publications · 620 citations

    5

    h-index

  5. MV
    Masoud Vedadi

    Structural Genomics Consortium, Canada

    5 publications · 620 citations

    5

    h-index

1–5 of 454

Institutions

154

  1. University of Toronto

    Toronto, Canada

    10 h-index

    69 publications

    7.7K citations

  2. University of Oxford

    Oxford, United Kingdom

    9 h-index

    62 publications

    3.8K citations

  3. Structural Genomics Consortium

    Toronto, Canada

    9 h-index

    57 publications

    6.8K citations

  4. Princess Margaret Cancer Centre

    Toronto, Canada

    7 h-index

    23 publications

    1.8K citations

  5. University Health Network

    Toronto, Canada

    6 h-index

    21 publications

    1.6K citations

  6. Genomics England

    London, United Kingdom

    5 h-index

    29 publications

    2.4K citations

  7. Genomics (United Kingdom)

    Oxford, United Kingdom

    4 h-index

    16 publications

    1.4K citations

  8. Universidad Nacional Autónoma de México

    Mexico City, Mexico

    4 h-index

    14 publications

    328 citations

1–8 of 154

Venues

  1. Journal of Medicinal Chemistry

    7 publications · 588 citations

    7

    h-index

  2. Analytical Chemistry

    5 publications · 149 citations

    5

    h-index

  3. ACS Chemical Biology

    4 publications · 129 citations

    4

    h-index

  4. Nature Communications

    4 publications · 597 citations

    4

    h-index

  5. Journal of the American Chemical Society

    JACS · 4 publications · 258 citations

    4

    h-index

1–5