A Low-Dose β1-Blocker in Combination with Milrinone Improves Intracellular Ca2+ Handling in Failing Cardiomyocytes by Inhibition of Milrinone-Induced Diastolic Ca2+ Leakage from the Sarcoplasmic Reticulum - Concepedia

Concepedia

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A Low-Dose β1-Blocker in Combination with Milrinone Improves Intracellular Ca2+ Handling in Failing Cardiomyocytes by Inhibition of Milrinone-Induced Diastolic Ca2+ Leakage from the Sarcoplasmic Reticulum

DOI Full Paper Access

23

Citations

30

References

2015

Year

Shigeki Kobayashi, Takehisa Susa, Hironori Ishiguchi, Takeki Myoren, Wakako Murakami, Takayoshi Kato, Masakazu Fukuda, Akihiro Hino, Takeshi Suetomi, Makoto Ono,

Abstract

A low-dose β1-blocker in combination with milrinone improved cardiac function in failing cardiomyocytes, apparently by inhibiting the phosphorylation of RyR2, not PLB, and subsequent diastolic Ca(2+) leak.

References

	Year	Citations

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