Takayoshi Kato

Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity

Tetsuro Oda, Yi Yang, Hitoshi Uchinoumi et al. · Journal of Molecular and Cellular Cardiology · 2015 · 107 citations · Full text

Molecular Pharmacology, Molecular Physiology, Signal Transduction +8

Enhancing calmodulin binding to cardiac ryanodine receptor completely inhibits pressure-overload induced hypertrophic signaling

Michiaki Kohno, Shigeki Kobayashi, Takeshi Yamamoto et al. · Communications Biology · 2020 · 38 citations · Full text

Enhanced binding of calmodulin to RyR2 corrects arrhythmogenic channel disorder in CPVT-associated myocytes

Masakazu Fukuda, Takeshi Yamamoto, Shigehiko Nishimura et al. · Biochemical and Biophysical Research Communications · 2014 · 33 citations

Cardiac Muscle, Signal Transduction, Molecular Physiology +8

Stabilization of RyR2 maintains right ventricular function, reduces the development of ventricular arrhythmias, and improves prognosis in pulmonary hypertension

Shinji Tanaka, Takeshi Yamamoto, Mei Mikawa et al. · Heart Rhythm · 2022 · 31 citations

Hypertension, Heart Failure, Ventricular Arrhythmias +14

Enhanced binding of calmodulin to the ryanodine receptor corrects contractile dysfunction in failing hearts

Akihiro Hino, Masafumi Yano, Takayoshi Kato et al. · Cardiovascular Research · 2012 · 29 citations · Full text