SAR of a novel ‘Anthranilamide Like’ series of VEGFR-2, multi protein kinase inhibitors for the treatment of cancer

Mutations of the BRAF gene in human cancer

Helen Davies, Graham R. Bignell, Charles Cox et al. · Nature · 2002 · 10.7K citations

Medicine, Genetics, Molecular Genetics +12

Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF

Paul Wan, Mathew J. Garnett, S. Mark Roe et al. · Cell · 2004 · 2.8K citations · Full text

Medicine, Molecular Biology, Oncology +14

Stem Cell Factor/c-kit Signaling Promotes the Survival, Migration, and Capillary Tube Formation of Human Umbilical Vein Endothelial Cells

Junji Matsui, Toshiaki WAKABAYASHI, Makoto Asada et al. · Journal of Biological Chemistry · 2004 · 218 citations · Full text

Life Sciences, Cell Biology, Pharmacology +16

Identification of a new chemical class of potent angiogenesis inhibitors based on conformational considerations and database searching

Pascal Furet, Guido Bold, Francesco Hofmann et al. · Bioorganic & Medicinal Chemistry Letters · 2003 · 63 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +17

VEGF receptor kinase inhibitors: phthalazines, anthranilamides and related structures

Jacques Dumas, Julie Dixon · Expert Opinion on Therapeutic Patents · 2005 · 26 citations

Medicine, Medicinal Chemistry, Oncology +17