Identification of potent, selective, CNS-targeted inverse agonists of the ghrelin receptor

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

Masayasu Kojima, Hiroshi Hosoda, Yukari Date et al. · Nature · 1999 · 8.5K citations

Life Sciences, Biochemistry, Endocrinology +10

Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist

Kazuko Haga, Andrew C. Kruse, Hidetsugu Asada et al. · Nature · 2012 · 795 citations · Full text

Medicine, Neuroscience, Pharmacology +10

Structure−Function Studies on the New Growth Hormone-Releasing Peptide, Ghrelin:  Minimal Sequence of Ghrelin Necessary for Activation of Growth Hormone Secretagogue Receptor 1a

Maria A. Bednarek, Scott D. Feighner, Sheng‐Shung Pong et al. · Journal of Medicinal Chemistry · 2000 · 551 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

In Vitro P-glycoprotein Assays to Predict the in Vivo Interactions of P-glycoprotein with Drugs in the Central Nervous System

Bo Feng, Jessica B. Mills, Ralph E. Davidson et al. · Drug Metabolism and Disposition · 2007 · 442 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Ghrelin Suppresses Glucose-Stimulated Insulin Secretion and Deteriorates Glucose Tolerance in Healthy Humans

Jenny Tong, Ronald L. Prigeon, Harold W. Davis et al. · Diabetes · 2010 · 326 citations · Full text

Medicine, Endocrinology, Nutritional Sciences +15