Clinical Applications of Polymeric Micelle Carrier Systems in Chemotherapy and Image Diagnosis of Solid Tumors

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

Yasuhiro Matsumura, Hiroshi Maeda · PubMed · 1986 · 6.8K citations

Medicine, Oncology, Pharmacology +12

Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.

Harold F. Dvorak, Lawrence F. Brown, Michael Detmar et al. · PubMed · 1995 · 3.1K citations

Veterinary Medicine, Physiology, Tumor Microenvironment +9

Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression

Lars Holmgren, Michael S. O’Reilly, Judah Folkman · Nature Medicine · 1995 · 1.9K citations

Medicine, Cancer Biology, Oncology +14

Poly(styrene-ethylene oxide) block copolymer micelle formation in water: a fluorescence probe study

Cheng Le Zhao, Yongcai Wang, Renliang Xu et al. · Macromolecules · 1991 · 1.3K citations

Natural Sciences, Chemistry, Materials Science +16

Identification and characterization of the blood vessels of solid tumors that are leaky to circulating macromolecules.

Harold F. Dvorak, Janice A. Nagy, J. Dvorák et al. · PubMed · 1988 · 681 citations

Medicine, Cancer Biology, Oncology +14