Concepedia

Optimization of novel nipecotic bis(amide) inhibitors of the Rho/MKL1/SRF transcriptional pathway as potential anti-metastasis agents

Jessica L. Bell, Andrew J. Haak, Susan M. Wade, Paul D. Kirchhoff, Richard R. Neubig, Scott D. Larsen

Bioorganic & Medicinal Chemistry Letters · 2013 · 68 citations · 15 references

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References

15

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

Masayoshi Uehata, Toshimasa Ishizaki, Hiroyuki Satoh et al. · Nature · 1997 · 2.9K citations

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Genomic analysis of metastasis reveals an essential role for RhoC

Edwin Clark, Todd R. Golub, Eric S. Lander et al. · Nature · 2000 · 1.4K citations

, , +12

Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis

Souhila Medjkane, Cristina Pérez-Sánchez, Cédric Gaggioli et al. · Nature Cell Biology · 2009 · 416 citations

, , +13

ERK-MAPK signaling coordinately regulates activity of Rac1 and RhoA for tumor cell motility

Emmanuel Vial, Erik Sahai, Christopher J. Marshall · Cancer Cell · 2003 · 410 citations · Full text

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RhoC GTPase, a novel transforming oncogene for human mammary epithelial cells that partially recapitulates the inflammatory breast cancer phenotype.

Zhi-Fen Wu, XiaoTan Qiao, Liwen Bao et al. · PubMed · 2000 · 320 citations

, , +13