Concepedia

The discovery of potent, selective, and orally bioavailable hNK1 antagonists derived from pyrrolidine

Peter Lin, Lehua Chang, Robert J. DeVita, Jonathan R. Young, Ronsar Eid, Xinchun Tong, Song Guo Zheng, Richard G. Ball, Nancy N. Tsou, Gary G. Chicchi,

Bioorganic & Medicinal Chemistry Letters · 2007 · 13 citations · 15 references

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15

An unidentified depressor substance in certain tissue extracts

U. S. von Euler, J. H. Gaddum · The Journal of Physiology · 1931 · 1.6K citations · Full text

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Transition-metal peroxide reactions. Synthesis of .alpha.-hydroxycarbonyl compounds from enolates

Edwin Vedējs, D. A. Engler, J. E. Telschow · The Journal of Organic Chemistry · 1978 · 326 citations

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Activity and Distribution of Binding Sites in Brain of a Nonpeptide Substance P (NK <sub>1</sub> ) Receptor Antagonist

Stafford McLean, Alan H. Ganong, Thomas Seeger et al. · Science · 1991 · 218 citations

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Tachykinin NK1 receptor antagonists act centrally to inhibit emesis induced by the chemotherapeutic agent cisplatin in ferrets

F.D. Tattersall, Wayne Rycroft, B. Francis et al. · Neuropharmacology · 1996 · 211 citations

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Structural Optimization Affording 2-(<i>R</i>)-(1-(<i>R</i>)-3,5-Bis(trifluoromethyl)phenylethoxy)-3-(<i>S</i>)-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a Potent, Orally Active, Long-Acting Morpholine Acetal Human NK-1 Receptor Antagonist

Jeffrey J. Hale, Sander G. Mills, Malcolm MacCoss et al. · Journal of Medicinal Chemistry · 1998 · 205 citations · Full text

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