Tachykinin NK1 receptor antagonists act centrally to inhibit emesis induced by the chemotherapeutic agent cisplatin in ferrets

F.D. Tattersall, Wayne Rycroft, B. Francis, +13

Neuropharmacology

Signal TransductionSignaling PathwayMedicineCell InteractionImmunology +4

Receptor-binding radiotracers: a class of potential radiopharmaceuticals.

W.C. Eckelman, Richard C. Reba, Raymond E. Gibson, +4

Munich Personal RePEc Archive (Ludwig Maximilian University of Munich)

EngineeringEstrogen ReceptorPharmacotherapyReceptor-binding RadiotracersReceptor Concentration +14

Kinetic Analysis of 3-Quinuclidinyl 4-[¹²⁵I]Iodobenzilate Transport and Specific Binding to Muscarinic Acetylcholine Receptor in Rat Brain in vivo: Implications for Human Studies

Yasufumi Sawada, Shin‐ichiro Hiraga, B. Francis, +9

Journal of Cerebral Blood Flow & Metabolism

Synthesis and evaluation of radioiodinated derivatives of 1-azabicyclo[2.2.2]oct-3-yl .alpha.-hydroxy-.alpha.-(4-iodophenyl)-.alpha.-phenylacetate as potential radiopharmaceuticals

Waclaw J. Rzeszotarski, W.C. Eckelman, B. Francis, +7

Journal of Medicinal Chemistry

Synthesis and evaluation of (17.alpha.,20E)-21-[125I]iodo-19-norpregna-1,3,5(10),20-tetraene-3,17-diol and (17.alpha.,20E)-21-[125I]iodo-11.beta.-methoxy-19-norpregna-1,3,5(10),20-tetraene-3,17-diol [17.alpha.-iodovinyl)estradiol derivatives] as high specific activity potential radiopharmaceuticals

Iwao Nakatsuka, N. L. FERREIRA, W.C. Eckelman, +5

Journal of Medicinal Chemistry

Estrogen ReceptorsMedicinal ChemistryDerivative (Chemistry)Natural SciencesDerivatives 4B +10

Use of 3-quinuclidinyl 4-iodobenzilate as a receptor binding radiotracer.

W.C. Eckelman, Robert R. Eng, Waclaw J. Rzeszotarski, +3

PubMed

NeurotransmitterOrganic ChemistryPharmacotherapyExperimental PharmacologySocial Sciences +18

In Vivo Competition Studies with Analogues of 3-Quinuclidinyl Benzilate

William C. Eckelman, M. Grissom, J.L. Conklin, +6

Journal of Pharmaceutical Sciences

MedicineOrganic ChemistryVivo Competition StudiesHeterocycle ChemistryPharmacology +2

Radioiodinated estrogen derivatives.

J. Krijn Mazaitis, R.E. Gibson, TORU KOMAI, +3

PubMed

Estrogen ReceptorChemical ModificationGynecologyPharmacotherapyEstrogen Derivatives +15

[77Br]-17-α-Bromoethynylestradiol: In vivo and In vitro characterization of an estrogen receptor radiotracer

R.E. Gibson, W.C. Eckelman, B. Francis, +4

International Journal of Nuclear Medicine and Biology

Vitro CharacterizationMedicineHormonal ReceptorRadiopharmaceutical TherapyEstrogen Receptor Radiotracer +6

[125I]17-alpha-iodovinyl 11-beta-methoxyestradiol interaction in vivo with estrogen receptors in hormone-independent MCF-7 human breast cancer transfected with the v-rasH oncogene.

Mary E. McManaway, Elaine M. Jagoda, A Kasid, +6

PubMed

Breast OncologyEstrogen ReceptorGynecologyTumor BiologyRadiopharmaceutical Therapy +16