Novel CADD-based peptidyl vinyl ester derivatives as potential proteasome inhibitors

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

Kenneth L. Rock, Colette F. Gramm, Lisa Rothstein et al. · Cell · 1994 · 2.5K citations

Life Sciences, Biochemistry, Immunology +14

Structure of 20S proteasome from yeast at 2.4Å resolution

M. Groll, Lars Ditzel, Jan Löwe et al. · Nature · 1997 · 2.3K citations

Life Sciences, Biochemistry, Molecular Biology +10

Crystal Structure of the 20 <i>S</i> Proteasome from the Archaeon <i>T. acidophilum</i> at 3.4 Å Resolution

Jan Löwe, Daniela Stock, Bing K. Jap et al. · Science · 1995 · 1.5K citations

Humanities, Anthropology, Archaeology +17

Potent and selective inhibitors of the proteasome: Dipeptidyl boronic acids

Julian Adams, Mark L. Behnke, Shaowu Chen et al. · Bioorganic & Medicinal Chemistry Letters · 1998 · 683 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +12

The Structure of the Mammalian 20S Proteasome at 2.75 Å Resolution

Masaki Unno, Tsunehiro Mizushima, Y. Morimoto et al. · Structure · 2002 · 521 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +11